Enantioselective Thiourea-Catalyzed Intramolecular Cope-Type Hydroamination
نویسندگان
چکیده
منابع مشابه
Gold(I)-Catalyzed Enantioselective Intramolecular Hydroamination of Allenes with Ureas.
Enantioselective intramolecular hydroamination of N-allenyl ureas catalyzed by an enantiomerically enriched bis(gold) phosphine complex forms pyrrolidine derivatives in good yield with up to 93% ee.
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A one-pot condensation of isotryptamines and aldehydes that affords enantiomerically enriched 4-substituted tetrahydro-γ-carbolines is reported. The reaction is induced by a chiral thiourea/benzoic acid dual catalyst system. Purification of the N-Boc-protected products by trituration or crystallization provides the optically pure tetrahydro-γ-carboline derivatives in a scalable and highly pract...
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N-Alkenyl carboxamides undergo gold-catalyzed intramolecular exo-hydroamination to form nitrogen heterocycles in excellent yield.
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2013
ISSN: 0002-7863,1520-5126
DOI: 10.1021/ja402893z